Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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Nephrol. Dial. Transplant. · Oct 2012
Circulating cell-free DNA in hemodialysis patients predicts mortality.
Circulating cell-free DNA (CFD) appears following cell damage and DNA release, and increases in hemodialysis (HD) patients particularly following HD. We hypothesized that CFD is an integrative marker of tissue damage and can be an independent predictor for all-cause mortality in HD patients. ⋯ Post-dialysis CFD level is an independent predictor of all-cause mortality in patients undergoing HD. We propose that CFD detection is an inexpensive applicable tool for identifying patients at risk and their follow-up.
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Nephrol. Dial. Transplant. · Oct 2012
Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria.
There is little data on the assessment of prediabetes with proteinuria. ⋯ Prediabetes is a significant risk factor for proteinuria compared with completely normal glucose level, and subjects with prediabetes defined using IFG are at significantly higher risk for proteinuria than those defined by HbA1c only.
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Nephrol. Dial. Transplant. · Oct 2012
Short-term change in kidney function and risk of end-stage renal disease.
It is unclear what degree of change in the eGFR over a 1-year period indicates clinically significant progression, and whether this change adds additional information beyond that obtained by a single eGFR measure alone. ⋯ A change in eGFR category accompanied by ≥25% decline (certain drop) is associated with increased ESRD risk. However, this elevated risk is captured by patient characteristics and eGFR at the last visit, suggesting that eGFR trajectories based on more than two serum creatinine measurements over a period longer than 1 year are required to determine ESRD risk and allow more reliable risk prediction.
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Nephrol. Dial. Transplant. · Oct 2012
Albuminuria increases cystatin C excretion: implications for urinary biomarkers.
Low-molecular weight (LMW) proteins, including albumin and novel urinary biomarkers of acute kidney injury (AKI) such as cystatin C and neutrophil gelatinase-associated lipocalin (NGAL), are normally absorbed from the glomerular filtrate by receptor-mediated transport. We evaluated the effect of albuminuria on urinary excretion of novel biomarkers. ⋯ Proteinuria may increase the threshold for detection of AKI by increasing the excretion of LMW protein biomarkers.