Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jan 2015
Hypercoagulability following major partial liver resection - detected by thrombomodulin-modified thrombin generation testing.
Conventional coagulation tests are frequently prolonged after liver surgery, suggesting a post-operative hypocoagulability. However, these tests are unreliable for assessment of the haemostatic status in these patients. In contrast, thrombin generation testing measures the true balance between pro- and anti-coagulant factors. ⋯ Thrombin generation in the presence of thrombomodulin revealed hypercoagulability in patients following liver resection. These results support the recently advocated restrictive use of plasma during liver resection and the exploration of more extensive use of post-operative thrombosis prophylaxis.