Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Nov 2018
Multicenter StudyPrevalence and clinical characteristics of refractoriness to optimal proton pump inhibitor therapy in non-erosive reflux disease.
The real size of the gastro-oesophageal reflux disease (GERD) population not responding to proton pump inhibitor (PPI) therapy has still not been fully elucidated. Causes of PPI refractoriness include incorrect diagnosis and lack of adherence to therapy, in terms of incorrect dosage and timing. ⋯ True refractoriness in patients with GERD symptoms attending a secondary care setting is lower than previously reported. Following a careful history and optimal PPI dosing, the rate of refractoriness was 20%. True NERD constitutes only a third of the PPI-refractory group.
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Aliment. Pharmacol. Ther. · Nov 2018
Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany.
Advanced fibrosis has been established as the most important predictor of overall mortality in patients with non-alcoholic fatty liver disease (NAFLD). In contrast to cirrhosis, advanced, non-cirrhotic NAFLD is difficult to identify and data from Germany are lacking. ⋯ The prevalence of metabolic comorbidities in a German population with non-cirrhotic biopsy-proven NAFLD is high. While the examined scores exhibit an acceptable specificity, liver stiffness measurement appeared to be superior to blood-based non-invasive surrogate scores in ruling out advanced fibrosis.
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Aliment. Pharmacol. Ther. · Nov 2018
Retraction Of PublicationRetraction: Randomised clinical trial: The clinical efficacy and safety of an alginate-antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China by J. Sun, C. Yang, H. Zhao, P. Zheng, J. Wilkinson, B. Ng, Y. Yuan. Aliment Pharmacol Ther. 2015;42:845-854.
The above article from Alimentary Pharmacology & Therapeutics, published online on 31 July 2015 on Wiley Online Library (wileyonlinelibrary.com), and in Volume 42, pp. 845-854, has been retracted by agreement between the authors, J. Sun, C. Yang, H. ⋯ W. Howden, and John Wiley Sons Ltd. The retraction has been agreed upon following major protocol deviations at some study sites and several instances of non-compliance that are sufficiently serious to warrant the withdrawal of the Chinese New Drug Application for Gaviscon Double Action.
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Aliment. Pharmacol. Ther. · Oct 2018
Short and long-term effectiveness and safety of vedolizumab in inflammatory bowel disease: results from the ENEIDA registry.
Effectiveness of vedolizumab in real world clinical practice is unknown. ⋯ Over 60% of IBD patients respond to vedolizumab. Many patients discontinue treatment over time. CD and disease burden impair both short- and long-term response. Vedolizumab seems to be safe in clinical practice.
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Aliment. Pharmacol. Ther. · Sep 2018
ReviewReview article: systemic treatment of hepatocellular carcinoma.
The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic therapy to show a survival benefit in patients with advanced hepatocellular carcinoma. Since then many drugs failed in the first- and second-line setting and it took almost another decade until further tyrosine kinase inhibitors succeeded in phase III trials. ⋯ The tyrosine kinase inhibitors sorafenib (first line) and regorafenib (second line) have been approved for hepatocellular carcinoma, and the immune checkpoint inhibitor nivolumab obtained conditional approval for sorafenib-experienced patients in the United States. With lenvatinib in the first line, and cabozantinib and ramucirumab in sorafenib-experienced patients, three more targeted therapies reached their primary endpoint in phase III trials and may soon be added to the treatment armamentarium.