Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Sep 2018
Pregnancy and birth outcomes in a Danish nationwide cohort of women with autoimmune hepatitis and matched population controls.
Many patients with autoimmune hepatitis are women of fertile age. Some concerns of these patients are related to pregnancy. ⋯ In Danish women with autoimmune hepatitis, fertility was unaffected. They had an increased risk of preterm birth and small for gestational age children, but not of congenital malformations or stillbirth.
-
Aliment. Pharmacol. Ther. · Aug 2018
Meta AnalysisSystematic review and network meta-analysis: first- and second-line biologic therapies for moderate-severe Crohn's disease.
There are limited data to inform positioning of agents for treating moderate-severe Crohn's disease (CD). ⋯ Indirect comparisons suggest that infliximab or adalimumab may be preferred first-line agents, and ustekinumab a preferred second-line agent, for induction of remission in patients with moderate-severe CD. Head-to-head trials are warranted.