Alimentary pharmacology & therapeutics
The most recent articles from:
Aliment. Pharmacol. Ther.
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Aliment. Pharmacol. Ther. · Mar 2017
ReviewReview article: dose optimisation of infliximab for acute severe ulcerative colitis.
Although optimal medical management of acute severe ulcerative colitis (UC) is ill-defined, infliximab has become a standard of care. Accumulating evidence suggests an increased rate of infliximab clearance in patients with acute severe UC and a reduced colectomy rate with an intensified infliximab induction regimen. ⋯ Uncontrolled studies suggest a benefit for infliximab dose optimisation in patients with acute severe UC. A randomised controlled trial in acute severe UC patients comparing a personalised infliximab dose-optimisation strategy with conventional dosing is a research priority.