Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2013
Comparative StudyThe management of alcoholic hepatitis: a prospective comparison of scoring systems.
The assessment of alcoholic hepatitis remains controversial. Several scores have been developed or used for this purpose. ⋯ In this single-centre study, a GAHS ≥9 identified patients who may benefit from treatment of alcoholic hepatitis. Intention-to-treat randomised-controlled trials using a GAHS ≥9 as the threshold for treatment are needed to validate these findings. Response to corticosteroids can be assessed using the Lille Score or by a 25% fall in bilirubin.
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Evidence about the beneficial effects of statins on reducing infections is accumulating. Identifying ways to reduce infection risk in patients with cirrhosis is important because of increased mortality risk and costs associated with infections. ⋯ Infections are a major concern among cirrhotic patients and have the potential to seriously impact both life expectancy and quality of life. Statin use may potentially reduce the risk of infections among patients with cirrhosis.