Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2012
Case ReportsMesenteric phlebosclerosis associated with long-term oral intake of geniposide, an ingredient of herbal medicine.
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. ⋯ The long-term use of geniposide in herbal medicines appears to be associated with mesenteric phlebosclerosis.
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Aliment. Pharmacol. Ther. · Sep 2012
Anti-tumour necrosis factor treatment of inflammatory bowel disease in liver transplant recipients.
Ulcerative colitis (UC) and Crohn's disease can sometimes relapse and be refractory to standard treatment following orthotopic liver transplantation (OLT) despite post-transplantation immunosuppressive therapy. ⋯ Starting Anti-TNF therapy following orthotopic liver transplantation appears to be a potential option for inflammatory bowel disease management. Additional studies are needed, however, to confirm these findings and to further assess risks associated with this treatment strategy.
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Aliment. Pharmacol. Ther. · Aug 2012
Randomized Controlled TrialRandomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study.
The eradication rate of Helicobacter pylori with standard treatments are decreasing worldwide. ⋯ In this randomised clinical trial simvastatin as adjuvant to standard therapy improves significantly the H. pylori eradication rate.
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Aliment. Pharmacol. Ther. · Jul 2012
Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD.
Conventional magnetic resonance imaging (MRI) techniques that measure hepatic steatosis are limited by T1 bias, T(2)* decay and multi-frequency signal-interference effects of protons in fat. Newer MR techniques such as the proton density-fat fraction (PDFF) that correct for these factors have not been specifically compared to liver biopsy in adult patients with non-alcoholic fatty liver disease (NAFLD). ⋯ MRI-determined proton density-fat fraction correlates with histology-determined steatosis grade in adults with NAFLD. Steatosis is non-linearly related to fibrosis progression. In patients with NAFLD, a low amount of hepatic steatosis on imaging does not necessarily indicate mild disease.