Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jul 2007
Randomized Controlled TrialA randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol.
Previous studies have suggested that therapeutic doses of paracetamol (acetaminophen) are safe in alcoholic patients when administered for up to 3 days. However, 14 days of therapeutic doses of paracetamol has been associated with an increase in serum transaminases. ⋯ Therapeutic dosing of paracetamol administered for 10 days appears to elevate serum ALT in moderate drinkers, but does not produce clinically evident liver injury.
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Aliment. Pharmacol. Ther. · Jul 2007
ReviewSystematic review: the adverse effects of sodium phosphate enema.
Sodium-phosphate enemas are widely used to treat constipation, and are rarely associated with side effects. ⋯ The main side effects caused by sodium phosphate enemas are water and electrolyte disturbances. The main risk factors are extreme age and associated comorbidity.
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Aliment. Pharmacol. Ther. · Jun 2007
Randomized Controlled Trial Multicenter StudyLubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety.
Lubiprostone, a locally acting type-2 chloride channel activator, induces intestinal fluid secretion. ⋯ Lubiprostone improved SBM rates in a dose-dependent manner. AEs were tolerable for most patients. Increased AE severity at 72 mcg/day did not provide a clear risk-to-benefit advantage compared with lubiprostone 48 mcg/day, the dose chosen for subsequent Phase 3 studies.
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Aliment. Pharmacol. Ther. · May 2007
Positive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population.
Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases which may be related. ⋯ There is a positive association between gastro-oesophageal reflux disease and irritable bowel syndrome, and their association occurs predominantly in male subjects.
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Aliment. Pharmacol. Ther. · Apr 2007
Review Meta AnalysisMeta-analysis: Lactobacillus GG for treating acute diarrhoea in children.
To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. ⋯ The use of LGG is associated with moderate clinical benefits in the treatment of acute diarrhoea in children. These findings should be interpreted with caution due to the important methodological limitations and heterogeneity of most of the studies.