Archives of gynecology and obstetrics
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Arch. Gynecol. Obstet. · Aug 2014
Multicenter Study Comparative StudyInterest of human papillomavirus DNA quantification and genotyping in paired cervical and urine samples to detect cervical lesions.
Cervical cancer is caused by persistent infection with high-risk human papillomavirus (HR-HPV). Conventional human papillomavirus (HPV) testing requires cervical sampling. However, vaginal and urine self-sampling methods are more acceptable for patients and result in increased participation when they are available in screening programs. In this context, we have developed a non-invasive screening method via the detection of HPV DNA in urine samples. ⋯ High concordance rates for HPV-DNA quantification and high/low-risk HPV genotyping in paired urine/cervical samples suggest that urinary HPV DNA testing could be useful for cervical lesion screening.