AIDS
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To estimate the potential direct cost of making triple combination antiretroviral therapy widely available to HIV-positive adults and children living in countries throughout the world. ⋯ Our results demonstrate that the cost of making combination antiretroviral therapy available worldwide would be exceedingly high, especially in countries with limited financial resources.
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Comparative Study
Mother-to-child transmission of HIV: implications of variation in maternal infectivity.
To examine the implications of variation in maternal infectivity on the timing of mother-to-child HIV transmission through breastfeeding. ⋯ Our model has helped identify a previously unrecognized determinant of the timing of breastfeeding-related HIV transmission, which may have adverse implications for the effectiveness of certain interventions to reduce mother-to-child HIV transmission such as maternal antiretroviral therapy in breastfeeding populations and the early cessation of breastfeeding.
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Randomized Controlled Trial Clinical Trial
A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda.
To describe the design and first-round survey results of a trial of intensive sexually transmitted disease (STD) control to reduce HIV-1 incidence. ⋯ Testing the effects of STD control on AIDS prevention is feasible in this Ugandan setting.