Brain injury : [BI]
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Brain injury : [BI] · Jan 2012
Persistent hypogonadism influences estradiol synthesis, cognition and outcome in males after severe TBI.
Acute hypogonadotropic hypogonadism (AHH) occurs frequently after TBI, as does chronic hypogonadotropic hypogonadism. However, AHH and persistent hypogonadotropic hypogonadism (PHH) after TBI are not well studied. The objective of this study was to characterize longitudinal hormone profiles and the impact of AHH and PHH on outcome. ⋯ These results support screening for post-acute secondary hypogonadism and further research to assess the mechanisms underlying PHH and associated functional and cognitive deficits.
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Brain injury : [BI] · Jan 2012
Accuracy of the S100β protein as a marker of brain damage in traumatic brain injury.
This study tested the hypothesis that S100β is a useful screening tool for detecting intracranial lesion (IL) in patients with a normal level of consciousness after traumatic brain injury (TBI). ⋯ Within the first 6 hours post-TBI, serum S100β seems to be an effective biochemical indicator of IL in patients without a decrease in consciousness. These results indicate that higher S100β cut-off values substantially improve the clinical relevance of this protein.
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Brain injury : [BI] · Jan 2012
Lack of long-term fMRI differences after multiple sports-related concussions.
Mild traumatic brain injury (mTBI) or concussion has been acutely associated with several cognitive symptoms, including deficits in response inhibition, working memory and motor performance. The pervasiveness of these cognitive symptoms has been more controversial. The effects of multiple concussions on neuropsychological functioning and brain activation following at least 6-months post-mTBI were examined. ⋯ There were minimal differences between the two closely matched groups. Results point to the relative plasticity of younger adults' cognitive abilities following concussion.
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Brain injury : [BI] · Jan 2012
A 10-year follow-up study of patients with severe traumatic brain injury and dysautonomia treated with intrathecal baclofen therapy.
To describe the long-term disorders of consciousness in patients with dysautonomia and hypertonia treated with intrathecal baclofen therapy (IBT). ⋯ Recovery of good long-term consciousness is possible. A low level of consciousness recovery and the early development of severe and persistent symptoms of dysautonomia associated with hypertonia could be linked to poor long-term outcome.
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Brain injury : [BI] · Jan 2012
Reliability, validity and clinical usefulness of the BNI fatigue scale in mild traumatic brain injury.
The purpose of this study was to examine the reliability, validity and clinical usefulness of the Barrow Neurological Institute Fatigue Scale (BNI-FS) in patients with mild traumatic brain injuries (MTBI). ⋯ The BNI-FS is a relatively new, brief and highly reliable measure of fatigue.