Journal of clinical epidemiology
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Overwhelming evidence shows the quality of reporting of randomised controlled trials (RCTs) is not optimal. Without transparent reporting, readers cannot judge the reliability and validity of trial findings nor extract information for systematic reviews. Recent methodological analyses indicate that inadequate reporting and design are associated with biased estimates of treatment effects. ⋯ It presents the meaning and rationale for each new and updated checklist item providing examples of good reporting and, where possible, references to relevant empirical studies. Several examples of flow diagrams are included. The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials.
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We compared popular methods to handle missing data with multiple imputation (a more sophisticated method that preserves data). ⋯ As this study shows that simple methods to deal with missing data can lead to seriously misleading results, we advise to consider multiple imputation. The purpose of multiple imputation is not to create data, but to prevent the exclusion of observed data.
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Multicenter Study
Most of the Quality of Life in Essential Tremor Questionnaire (QUEST) psychometric properties resulted in satisfactory values.
This study sought to assess the psychometric attributes of the Quality of Life in Essential Tremor Questionnaire (QUEST) by undertaking an independent validation. ⋯ Apart from a substantial problem of acceptability, most of the tested psychometric attributes of the QUEST resulted satisfactory.