European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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Eur J Cardiothorac Surg · Jan 1993
Meta Analysis Comparative StudyOptimal antithrombotic therapy following aortocoronary bypass: a meta-analysis.
To evaluate the role of antithrombotic therapy, on preserving graft patency, we performed a meta-analysis of randomized clinical trials involving aspirin (ASA), dipyridamole (D), anticoagulants (AC) and placebo or nontreatment controls (P). Manual literature searches were performed supplemented by computerized MEDLINE listings complete to July 1991. Saphenous vein graft occlusion was determined by angiography (patients with > or = 1 distal anastomotic occlusion). ⋯ Early postoperative treatment (< or = 6 h) strongly influenced graft occlusion while preoperative administration provided no additional benefit. No mortality advantage was identified for any antithrombotic therapy. Aspirin or anticoagulants enhance saphenous vein graft patency following aortocoronary bypass surgery, and a combination thereof deserves further investigation in a trial large enough to detect the effects of these treatments with respect to clinical events.
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Eur J Cardiothorac Surg · Jan 1993
Editorial ReviewOrgan dysfunction and cardiopulmonary bypass: the role of complement and complement regulatory proteins.
Cardiopulmonary bypass-induced organ dysfunction remains a clinical problem in certain groups of patients. Although the pathogenesis is multifactorial, it is likely that a panendothelial injury consequent upon widespread humoral and cellular activation is a major contributor to this process. The biologically active products of complement activation are certainly capable of inducing many of the features of the post-perfusion syndrome. ⋯ Haworth, Personal Communication) whilst pre-existing sepsis could clearly induce a degree of endothelial dysfunction. A further possibility is that the inflammatory response in these patients is already "primed". Some patients with heart failure have been shown to have elevated circulating TNF.(ABSTRACT TRUNCATED AT 400 WORDS)
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Eur J Cardiothorac Surg · Jan 1993
Comparative StudyIntercostal nerve block, interpleural analgesia, thoracic epidural block or systemic opioid application for pain relief after thoracotomy?
The purpose of this study was to investigate the effect of different pain-relief methods (regional and systemic) following thoracotomies on the cardiovascular system, pulmonary gas exchange, various endocrine parameters and subjective perception. A further aspect was to evaluate the benefits of interpleural analgesia as a new regional technique against already established regional techniques, such as intercostal nerve block and thoracic epidural block. All postoperative pain methods led to a significant time-dependent reduction of the adrenaline concentrations in plasma while the noradrenaline concentrations did not change significantly. ⋯ The plasma concentrations of the "stress metabolites", such as glucose, free fatty acids and lactate, as well as the haemodynamic (mean arterial pressure, heart rate) and pulmonary parameters (blood gas analyses), showed no significant differences among groups. In contrast to the other pain-relieving methods, interpleural analgesia did not lead to sufficient pain relief in that 7 out of 10 patients needed supplementary systemic opioid therapy. Therefore, interpleural analgesia for pain relief following thoracotomies cannot be recommended.
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Eur J Cardiothorac Surg · Jan 1993
Case ReportsDelayed brachial plexus paralysis due to subclavian pseudoaneurysm after clavicular fracture.
Injuries to the brachial plexus and subclavian artery are serious complications of shoulder girdle trauma. Due to the close anatomical relationship between the brachial plexus and the subclavian artery in the thoracic outlet, both structures are often simultaneously involved in shoulder girdle injuries. Isolated lesions of the subclavian artery or the brachial plexus can also occur, especially with clavicular fractures. When a false subclavian aneurysm leads to a gradually increasing compression of the brachial plexus, the neurological signs and symptoms develop insidiously after the traumatic event.
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Eur J Cardiothorac Surg · Jan 1993
Comparative StudyRelationship between hemodynamics and blood volume changes after cardiopulmonary bypass during coronary artery bypass grafting.
The blood volume and central hemodynamics were assessed in 22 patients undergoing coronary artery bypass grafting before and after cardiopulmonary bypass. Patients were divided into two groups according to their blood volume after cardiopulmonary bypass. In group A (n = 10) the patients were hypovolemic and in group B (n = 12) the patients were hypervolemic after cardiopulmonary bypass. ⋯ There was a correlation between the changes in cardiac index and changes in total blood volume (r = 0.57; P < 0.01). Patients in neither group suffered from hypoxia. We conclude that extreme hemodilution after cardiopulmonary bypass must be normovolemic, and the pulmonary capillary wedge pressure or right atrial pressure as a guide for blood volume evaluation after termination of cardiopulmonary bypass may be misleading.