Journal of neurotrauma
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Journal of neurotrauma · Mar 2020
Taurine Promotes Axonal Regeneration after a Complete Spinal Cord Injury in Lampreys.
Taurine is one of the most abundant free amino acids in the brain. It is well known that taurine protects the brain from further damage after a traumatic event. However, only a few ex vivo studies have looked at the possible role of taurine in the regulation of axon regeneration after injury. ⋯ Based on these results, we decided to apply an acute taurine treatment at the site of injury to study its effect on axon regeneration. Results from these experiments show that an acute taurine treatment enhances axonal regeneration following SCI in lampreys. This offers a novel way to try to promote axon regeneration after nervous system injuries in mammalian models.
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Journal of neurotrauma · Mar 2020
Chronic, Twice-daily Dosing of an NK2 Receptor Agonist, [Lys5,MeLeu9,Nle10] NKA(4 10), Produces Consistent Drug-Induced Micturition and Defecation in Chronic Spinal Rats.
Acute administration of [Lys5,Me,Leu9,Nle10]-NKA(4-10) (LMN-NKA) produces contractions of the detrusor and rectum with voiding in intact and acutely spinal cord injured (SCI) rats. In the current study, the ability of LMN-NKA (10 μg/kg or 100 μg/kg, subcutaneous [SC], twice a day [bid]) or vehicle to induce voiding and defecation in chronic SCI rats was examined across 30 days. After the last day of administration, voiding response rates and bladder pressure (BP) responses to LMN-NKA (intravenous [IV] and SC) were evaluated under anesthesia. ⋯ No differences in bladder weights or collagen-to-smooth muscle ratios in histological sections were seen between the groups. Thus neither tolerance, nor sensitization, to LMN-NKA-induced micturition and defecation occurs with chronic administration in rats with chronic SCI. Efficacy was higher in male than in female rats.
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Journal of neurotrauma · Mar 2020
Corrrection to: Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network by Wilson, J.R., Jaja, B.N.R., Kwon, B.K., Guest, J.D., Harrop, J.S., Aarabi, B., Shaffrey, C.I., Badhiwala, J.H., Toups, E.G., Grossman, R.G., and Fehlings, M.G. J. Neurotrauma 2018;35(21):2554-2560. (DOI: 10.1089/neu.2017.5535).
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Journal of neurotrauma · Mar 2020
Correction to: Why Our Long-Term Functional Prognosis Tools Are a Valuable Contribution to the Traumatic Brain Injury Outcome Literature: Response to Foks et al. by Walker, W.C., Sima, A.P., Hoffman, J.M., Harrison-Felix, C., Agyemang, A.A., Stromberg, K.A., Marwitz, J.H., Brown, A.W., Graham, K.M., Merchant, R., and Kreutzer, J.S. J. Neurotrauma 2019;36(8):1384-1385. (DOI: 10.1089/neu.2018.6069).
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Journal of neurotrauma · Mar 2020
Correction to: Predicting Long-Term Global Outcome after Traumatic Brain Injury: Development of a Practical Prognostic Tool Using the Traumatic Brain Injury Model Systems National Database by Walker, W.C., Stromberg, K.A., Marwitz, J.H., Sima, A.P., Agyemang, A.A., Graham, K.M., Harrison-Felix, C., Hoffman, J.M., Brown, A.W., Kreutzer, J.S., and Merchant, R. J. Neurotrauma 2018;35(14):1587-1594. (DOI: 10.1089/neu.2017.5359).