Current opinion in immunology
-
Antigens that are selectively or abundantly expressed in cancer cells have been used for clinical trials, mostly in patients with advanced disease, and appear to be better vaccines than whole cells. Candidate vaccines have emerged from different categories of cancer antigens. ⋯ Although individual patients have benefited, no strategy has emerged as universally applicable; neither has any route of administration. Increasingly sensitive methods have correlated clinical responses with measurable immune responses to vaccination in some patients.
-
Curr. Opin. Immunol. · Oct 2001
Editorial ReviewThe state of immunology in Africa: HIV/AIDS and malaria.
HIV and malaria are two major infections that are responsible for the greatest burden of diseases, morbidity and mortality in the African population. Successful research has been undertaken in Africa into novel means of monitoring HIV disease progression and in identifying vaccine candidates. ⋯ It is hoped that vaccines for malaria will soon prove successful. However, many problems still face immunology research in Africa.
-
Curr. Opin. Immunol. · Oct 1996
ReviewGraft-versus-host effect after allogeneic hematopoietic stem cell transplantation: GVHD and GVL.
The development of a graft-versus-host reaction after allogeneic hematopoietic stem cell transplantation is an important determinant of the transplant outcome. A better understanding and improved management of the graft-versus-host reaction should allow improved prevention and treatment of graft-versus-host disease and the development of new strategies to enhance a graft-versus-leukemia effect and to decrease the incidence of leukemic relapse after transplantation.