BMJ : British medical journal
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Meta Analysis
Human albumin administration in critically ill patients: systematic review of randomised controlled trials.
To quantify effect on mortality of administering human albumin or plasma protein fraction during management of critically ill patients. ⋯ There is no evidence that albumin administration reduces mortality in critically ill patients with hypovolaemia, burns, or hypoalbuminaemia and a strong suggestion that it may increase mortality. These data suggest that use of human albumin in critically ill patients should be urgently reviewed and that it should not be used outside the context of rigorously conducted, randomised controlled trials.