BMJ : British medical journal
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To quantify efficacy and harm of pharmacological prevention of acute mountain sickness. ⋯ At above 4000 m, with a high ascent rate, fewer than three subjects need to be treated with prophylactic dexamethasone 8-16 mg or acetazolamide 750 mg for one subject not to experience acute mountain sickness who would have done so had they all received a placebo. Acetazolamide 500 mg does not work.
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To quantify the impact of NHS Direct on the use of accident and emergency, ambulance, and general practitioner cooperative services. ⋯ In its first year NHS Direct did not reduce the pressure on NHS immediate care services, although it may have restrained increasing demand on one important part-general practitioners' out of hours services.