BMJ : British medical journal
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Review Meta Analysis Comparative Study
Short term and intermediate term comparison of endarterectomy versus stenting for carotid artery stenosis: systematic review and meta-analysis of randomised controlled clinical trials.
To evaluate the relative short term safety and intermediate term efficacy of carotid endarterectomy versus carotid artery stenting. ⋯ Carotid endarterectomy was found to be superior to carotid artery stenting for short term outcomes but the difference was not significant for intermediate term outcomes; this difference was mainly driven by non-disabling stroke. Significantly fewer cranial nerve injuries and myocardial infarctions occurred with carotid artery stenting.
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Review Meta Analysis
Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis.
To systematically review the evidence that smoking cessation after diagnosis of a primary lung tumour affects prognosis. ⋯ This review provides preliminary evidence that smoking cessation after diagnosis of early stage lung cancer improves prognostic outcomes. From life table modelling, the estimated number of deaths prevented is larger than would be expected from reduction of cardiorespiratory deaths after smoking cessation, so most of the mortality gain is likely to be due to reduced cancer progression. These findings indicate that offering smoking cessation treatment to patients presenting with early stage lung cancer may be beneficial.
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Review Meta Analysis
Local anaesthesia for pain control during outpatient hysteroscopy: systematic review and meta-analysis.
To compare the effects of different types of local anaesthetic for pain control during outpatient hysteroscopy. ⋯ Paracervical local anaesthetic injection is the best method of pain control for women undergoing hysteroscopy as outpatients.
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Review Meta Analysis Comparative Study
Sutures versus staples for skin closure in orthopaedic surgery: meta-analysis.
To compare the clinical outcomes of staples versus sutures in wound closure after orthopaedic surgery. ⋯ After orthopaedic surgery, there is a significantly higher risk of developing a wound infection when the wound is closed with staples rather than sutures. This risk is specifically greater in patients who undergo hip surgery. The use of staples for closing hip or knee surgery wounds after orthopaedic procedures cannot be recommended, though the evidence comes from studies with substantial methodological limitations. Though we advise orthopaedic surgeons to reconsider their use of staples for wound closure, definitive randomised trials are still needed to assess this research question.
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Randomized Controlled Trial Multicenter Study
Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial.
To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). ⋯ Quadrivalent HPV vaccine provided sustained protection against low grade lesions attributable to vaccine HPV types (6, 11, 16, and 18) and a substantial reduction in the burden of these diseases through 42 months of follow-up.