BMJ : British medical journal
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To investigate the impact of industry funding on reporting of subgroup analyses in randomised controlled trials. ⋯ Industry funded randomised controlled trials, in the absence of statistically significant primary outcomes, are more likely to report subgroup analyses than non-industry funded trials. Industry funded trials less frequently prespecify subgroup hypotheses and less frequently test for interaction than non-industry funded trials. Subgroup analyses from industry funded trials with negative results for the primary outcome should be viewed with caution.
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Randomized Controlled Trial Multicenter Study
Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial.
To compare long term recurrence of cancer and survival of patients having major abdominal surgery for cancer. ⋯ Use of epidural block in abdominal surgery for cancer is not associated with improved cancer-free survival.
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Randomized Controlled Trial Multicenter Study
Improving cardiovascular health at population level: 39 community cluster randomised trial of Cardiovascular Health Awareness Program (CHAP).
To evaluate the effectiveness of the community based Cardiovascular Health Awareness Program (CHAP) on morbidity from cardiovascular disease. ⋯ A collaborative, multi-pronged, community based health promotion and prevention programme targeted at older adults can reduce cardiovascular morbidity at the population level. Trial registration Current controlled trials ISRCTN50550004.
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Review Comparative Study
Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study.
To compare the reported effect sizes of cardiovascular biomarkers in datasets from observational studies with those in datasets from randomised controlled trials. ⋯ Cardiovascular biomarkers often have less promising results in the evidence derived from randomised controlled trials than from observational studies.
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Randomized Controlled Trial Multicenter Study
Effectiveness of a multifaceted podiatry intervention to prevent falls in community dwelling older people with disabling foot pain: randomised controlled trial.
To determine the effectiveness of a multifaceted podiatry intervention in preventing falls in community dwelling older people with disabling foot pain. ⋯ A multifaceted podiatry intervention reduced the rate of falls in community dwelling older people with disabling foot pain. The components of the intervention are inexpensive and relatively simple to implement, suggesting that the programme could be incorporated into routine podiatry practice or multidisciplinary falls prevention clinics.