BMJ : British medical journal
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Randomized Controlled Trial Multicenter Study
Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.
To assess the effectiveness and safety of melatonin in treating severe sleep problems in children with neurodevelopmental disorders. ⋯ Children gained little additional sleep on melatonin; though they fell asleep significantly faster, waking times became earlier. Child behaviour and family functioning outcomes did not significantly improve. Melatonin was tolerable over this three month period. Comparisons with slow release melatonin preparations or melatonin analogues are required.