BMJ : British medical journal
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Review Meta Analysis
Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis.
To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection). ⋯ Published data assessing the risk of venous thromboembolism in women prescribed progestin-only contraception are limited. In this meta-analysis of eight observational studies, the use of progestin-only contraception was not associated with an increased risk of venous thromboembolism compared with non-users of hormonal contraception. The potential association between injectable progestins and thrombosis requires further study.
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Review Meta Analysis
Effectiveness of intervention on physical activity of children: systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54).
To determine whether, and to what extent, physical activity interventions affect the overall activity levels of children. ⋯ This review provides strong evidence that physical activity interventions have had only a small effect (approximately 4 minutes more walking or running per day) on children's overall activity levels. This finding may explain, in part, why such interventions have had limited success in reducing the body mass index or body fat of children.
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Review Meta Analysis
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
To assess the effect of tranexamic acid on blood transfusion, thromboembolic events, and mortality in surgical patients. ⋯ Strong evidence that tranexamic acid reduces blood transfusion in surgery has been available for many years. Further trials on the effect of tranexamic acid on blood transfusion are unlikely to add useful new information. However, the effect of tranexamic acid on thromboembolic events and mortality remains uncertain. Surgical patients should be made aware of this evidence so that they can make an informed choice.
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Randomized Controlled Trial Multicenter Study
Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial.
To determine whether a lifestyle integrated approach to balance and strength training is effective in reducing the rate of falls in older, high risk people living at home. ⋯ The LiFE programme provides an alternative to traditional exercise to consider for fall prevention. Functional based exercise should be a focus for interventions to protect older, high risk people from falling and to improve and maintain functional capacity.
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Review Meta Analysis
Shift work and vascular events: systematic review and meta-analysis.
To synthesise the association of shift work with major vascular events as reported in the literature. ⋯ Shift work is associated with vascular events, which may have implications for public policy and occupational medicine.