BMJ : British medical journal
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Review Meta Analysis
Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies.
To investigate the association between intake of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of breast cancer and to evaluate the potential dose-response relation. ⋯ Higher consumption of dietary marine n-3 PUFA is associated with a lower risk of breast cancer. The associations of fish and alpha linolenic acid intake with risk warrant further investigation of prospective cohort studies. These findings could have public health implications with regard to prevention of breast cancer through dietary and lifestyle interventions.
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Review Meta Analysis
Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis.
To estimate the disease burden of the most important complications of postoperative abdominal adhesions: small bowel obstruction, difficulties at reoperation, infertility, and chronic pain. ⋯ The review protocol was registered through PROSPERO (CRD42012003180).
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Review Meta Analysis
Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study.
To assess adjustment practices for primary outcomes of randomized controlled trials and their impact on the results. ⋯ There is large diversity on whether and how analyses of primary outcomes are adjusted in randomized controlled trials and these choices can sometimes change the nominal significance of the results. Registered protocols should explicitly specify adjustments plans for main outcomes and analysis should follow these plans.
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Review Meta Analysis
Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.
To evaluate the association of probiotic supplementation during pregnancy or infancy with childhood asthma and wheeze. ⋯ PROSPERO (CRD42013004385).
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Review Meta Analysis
Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis.
To evaluate risk factors for severe outcomes in patients with seasonal and pandemic influenza. ⋯ The level of evidence to support risk factors for influenza related complications is low and some well accepted risk factors, including pregnancy and ethnicity, could not be confirmed as risks. Rigorous and adequately powered studies are needed.