BMJ : British medical journal
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Observational Study
The association between kidney function and major bleeding in older adults with atrial fibrillation starting warfarin treatment: population based observational study.
To determine rates of major bleeding by level of kidney function for older adults with atrial fibrillation starting warfarin. ⋯ Reduced kidney function was associated with an increased risk of major bleeding among older adults with atrial fibrillation starting warfarin; excess risks from reduced eGFR were most pronounced during the first 30 days of treatment. Our results support the need for careful consideration of the bleeding risk relative to kidney function when assessing the risk-benefit ratio of warfarin treatment in people with chronic kidney disease and atrial fibrillation, particularly in the first 30 days of treatment.
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To investigate the associations of exercise capacity and muscle strength in late adolescence with risk of vascular disease and arrhythmia. ⋯ Exercise capacity and muscle strength in late adolescence are independently and jointly associated with long term risk of vascular disease and arrhythmia. The health benefit of lower risk of vascular events with higher exercise capacity was not outweighed by higher risk of arrhythmia.