BMJ : British medical journal
-
To identify the number of drug-disease and drug-drug interactions for exemplar index conditions within National Institute of Health and Care Excellence (NICE) clinical guidelines. ⋯ Drug-disease interactions were relatively uncommon with the exception of interactions when a patient also has chronic kidney disease. Guideline developers could consider a more systematic approach regarding the potential for drug-disease interactions, based on epidemiological knowledge of the comorbidities of people with the disease the guideline is focused on, and should particularly consider whether chronic kidney disease is common in the target population. In contrast, potentially serious drug-drug interactions between recommended drugs for different conditions were common. The extensive number of potentially serious interactions requires innovative interactive approaches to the production and dissemination of guidelines to allow clinicians and patients with multimorbidity to make informed decisions about drug selection.
-
Comparative Study
Austin Powers bites back: a cross sectional comparison of US and English national oral health surveys.
To compare oral health in the US and England and to assess levels of educational and income related oral health inequalities between both countries. ⋯ The oral health of US citizens is not better than the English, and there are consistently wider educational and income oral health inequalities in the US compared with England.