BMJ : British medical journal
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To define the region on human chromosome 19 carrying the gene for malignant hyperthermia susceptibility and to evaluate the use of flanking DNA markers in diagnosing susceptibility. ⋯ DNA markers flanking the gene for susceptibility to malignant hyperthermia can be used with high accuracy to diagnose susceptibility in subjects in large known malignant hyperthermia pedigrees and may replace the previous in vitro contracture test for diagnosing this inherited disorder in large families with malignant hyperthermia.
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To examine whether sodium pump activity plays a part in the pathogenesis of thyrotoxic periodic paralysis. ⋯ Sodium pump activity in untreated subjects with periodic paralysis is higher than in other thyrotoxic subjects, and this may be responsible for the hypokalaemia.
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Randomized Controlled Trial Clinical Trial
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
To see whether intravenous acetylcysteine would improve outcome in patients with fulminant hepatic failure after paracetamol overdose. ⋯ Acetylcysteine is safe and effective in fulminant hepatic failure after paracetamol overdose.