Gaceta sanitaria
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We analyzed the burden of disease in the elderly population in Spain in 2008. ⋯ Burden of disease analysis allows distinct health problems to be reassessed in relation to classical mortality analysis.
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The aim of this prospective study was to evaluate the validity, reliability and responsiveness of the Spanish version of the 7-item short-form of the function dimension of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). ⋯ The Spanish 7-item short form of the WOMAC function dimension is valid, reliable and responsive for patients with total joint replacement. The use of this version will reduce the burden on patients in both clinical studies and clinical practice.
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Comparative Study
[Temporal trend in understanding of and attitudes to advance directives in patients with chronic diseases].
To describe patients' degree of knowledge about their diseases and advance directives, as well as their willingness to write these documents, among patients with chronic diseases seen in the emergency department. ⋯ Patients with chronic diseases showed greater understanding of their disease in the second period but awareness of advance directives and willingness to write these documents remained low. Information on these issues should be improved as an essential part of the physician-patient relationship.
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We evaluated the cost-effectiveness of rituximab added to the chemotherapy regimen of fludarabine plus cyclophosphamide (R-FC) versus fludarabine plus cyclophosphamide (FC) for the treatment of patients with previously untreated or relapsed/refractory chronic lymphocytic leukemia (CLL). ⋯ In patients with previously untreated or relapsed/refractory CLL, the addition of rituximab to the FC regimen increased life expectancy and quality-adjusted life expectancy. In both types of patient, the treatment was cost-effective.