Journal of internal medicine
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Multicenter Study Observational Study
Clinical presentation, course, and prognosis of patients with mixed connective tissue disease: A multicenter retrospective cohort.
The objective of this study is to better characterize the features and outcomes of a large population of patients with mixed connective tissue disease (MCTD). ⋯ This study shows that MCTD is a distinct entity that can be classified using either Kasukawa or Sharp criteria, and that only 25.8% of patients progress to a dCTD during follow-up.
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Randomized Controlled Trial
Orthostatic blood pressure changes do not influence cognitive outcomes following intensive blood pressure control.
Effects of intensive blood pressure (BP) control on cognitive outcomes in patients with excess orthostatic BP changes are unclear. We aimed to evaluate whether orthostatic BP changes modified the effects of BP intervention on cognitive impairment. ⋯ Intensive BP control did not have a deteriorating effect on cognitive outcomes among hypertensive patients experiencing significant postural BP changes.