Journal of anesthesia
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Journal of anesthesia · Jun 1994
Administration of MgSO4 failed to improve the neurological recovery after complete global brain ischemia in dogs.
The cerebral protective effects of MgSO4 after complete global brain ischemia were evaluated with EEG, evoked potentials (EP) and the neurological recovery score (NRS) in the dog. Complete global brain ischemia for 15 min was achieved by occluding the ascending aorta and the caval veins. The MgSO4 group (N=7) were injected with a 10% MgSO4 solution and the control group (N=7) were administered a normal saline intravenously from the beginning of the resuscitation to 48 h after ischemia. ⋯ The NRSs (0=death, 100=normal) in the control group and the MgSO4 group were 50±3 (n=7) and 43±9 (n=7) on the 3rd day after ischemia, and were 56±5 (n=5) and 42±12 (n=5) on the 7th day. The differences between the two groups were not significant. We conclude that MgSO4 administered after ischemia has no beneficial effects on the recovery of EEG, EP and the NRS after 15 min of complete global brain ischemia in the dog.
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Journal of anesthesia · Jun 1994
An analysis of CO2 elimination curves during artificial ventilation.
We have developed some indices to evaluate the phase III slope in CO2 elimination curves. The indices were applied to 12 mechanically ventilated patients in ICU to determine their stability under various ventilator settings. Fco2-sl[30-90] and[Formula: see text] expressed the mean incline of phase III slope in Fco2-volume curves and[Formula: see text]-volume curves, respectively. ⋯ In the first study, Fco2-sl[30-90] and[Formula: see text][30-90] correlated with ETco2, Vd/Vt and the volume of CO2 expired, but Fco2-SR and[Formula: see text]-SR were independent of these parameters.[Formula: see text]-SR did not show any significant changes under various ventilator settings except for application of PEEP. In the second study, those with impaired preoperative respiratory function had significantly larger values for[Formula: see text].[Formula: see text] was as sensitive as parameters such as VD/VT, arterial to end-tidal CO2 tension difference (a-ET·Dco2), and volume pressure index (VPI) in prediting poor respiratory functions. We concluded that[Formula: see text] is a useful index for evaluating the phase III slope in CO2 elimination curves.