Journal of anesthesia
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Journal of anesthesia · Jun 1997
Possible evaluation of hemodynamic effects of the potassium channel opener KRN2391 on induced hypotension in dogs.
KRN2391 is potassium channel opener with a nitrate moiety which possesses potent vasodilatory action. The hemodynamic profiles of KRN2391-induced hypotension are still not well understood. The aim of this study was to investigate the potential use of KRN2391 for induced hypotension. ⋯ Left ventricular maximum dP/dt increased significantly during and after induced hypotension. Right atrial and mean pulmonary artery pressures increased significantly, whereas pulmonary capillary wedge pressure remained unchanged. The results of the present study show that KRN2391 is effective in reducing afterload during induced hypotension, and suggest that the hemodynamic profiles of KRN2391-induced hypotension are a hyperdynamic state as expressed by twofold increases in CI concomitant with the increase in right ventricular filling pressures.