Journal of anesthesia
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Journal of anesthesia · Jan 2005
Randomized Controlled Trial Clinical TrialPreadministration of low-dose ketamine reduces tourniquet pain in healthy volunteers.
We evaluated whether preadministration of low-dose ketamine could attenuate tourniquet pain and arterial pressure increase using high tourniquet pressure in ten healthy awake volunteers. Ketamine, 0.1 mg x kg(-1), or normal saline was given intravenously in a double-blind fashion before tourniquet inflation with a pressure of 400 mmHg at the thigh. ⋯ SBP (120 +/- 9 mmHg) significantly increased before tourniquet deflation (133 +/- 16 mmHg) in the saline trial, but not in the ketamine trial. The results show that preadministration of low-dose ketamine attenuates tourniquet pain and arterial pressure increase during high-pressure tourniquet application and prolongs tourniquet time in healthy volunteers.
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Journal of anesthesia · Jan 2005
Randomized Controlled Trial Clinical TrialLaryngeal mask airway can be inserted with inhaled desflurane induction.
In this prospective, randomized, controlled trial, we investigated the reliability of laryngeal mask airway (LMA) insertion with inhaled desflurane. ⋯ We demonstrated that inhaled desflurane when used with caution in a controlled manner provided acceptable conditions for LMA insertion.
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Journal of anesthesia · Jan 2005
Randomized Controlled Trial Comparative Study Clinical TrialHemodynamic and catecholamine response to a rapid increase in isoflurane or sevoflurane concentration during a maintenance phase of anesthesia in humans.
The purpose of this study was to compare hemodynamic and catecholamine changes due to a sudden increase in inhalation anesthetic concentrations (isoflurane and sevoflurane) during surgery. ⋯ During surgery a sudden increase in isoflurane concentration induced larger changes in hemodynamics and sympathetic nerve activity than sevoflurane.
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Journal of anesthesia · Jan 2005
Randomized Controlled Trial Clinical TrialInsulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner.
The dose-dependent effects of sevoflurane and isoflurane anesthesia on glucose tolerance were compared in humans. ⋯ Sevoflurane anesthesia impairs glucose tolerance to the same degree as does isoflurane anesthesia. Glucose intolerance during sevoflurane or isoflurane anesthesia is independent of agent and dosage up to 1.5 MAC.
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Journal of anesthesia · Jan 2005
Randomized Controlled Trial Clinical TrialEfficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy.
Local epinephrine infiltration often causes beta1-adrenoceptor-mediated tachycardia, hypertension, and arrhythmia. Landiolol, a short acting beta1-adrenoceptor blocker, may represent the most ideal agent to attenuate these adverse effects. In this study, we examined the effects of landiolol on the hemodynamic changes resulting from local infiltration of epinephrine. ⋯ The present study suggests that landiolol 10 mg may be a more suitable dose than landiolol 5 mg to antagonize hyperdynamic states induced by local administration of epinephrine.