Journal of anesthesia
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Journal of anesthesia · Dec 2019
Comparative StudyTwo-stage goal-directed therapy protocol for non-donor open hepatectomy: an interventional before-after study.
Hemodynamic management during low central venous pressure (L-CVP)-assisted hepatectomy involves fluid restriction during resection and fluid resuscitation after resection. Recently, high stroke volume variation (SVV) has been reported as an alternative to L-CVP for reducing blood loss during a hepatectomy. The current study evaluated the impact of a newly implemented SVV-based goal-directed therapy (GDT) protocol on blood loss during hepatectomy. ⋯ Compared to conventional management, SVV-guided GDT may reduce blood loss during hepatectomies.
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Journal of anesthesia · Dec 2019
Distinct, sex-dependent miRNA signatures in piglet hippocampus induced by a clinically relevant isoflurane exposure: a pilot study.
To evaluate the effects of sex on miRNA expression in the hippocampus after isoflurane anesthesia in a neonatal piglet model. ⋯ In the neonatal piglet hippocampus, miRNA expression was highly conserved. There was no overlap in miRNA expression between isoflurane-exposed males and females, suggesting sex differences in isoflurane-induced miRNA expression. These results support the hypothesis that a clinically relevant exposure to isoflurane induces distinct miRNA signatures in the hippocampus of neonatal male and female piglets. Their functional relevance in anesthesia-induced neurotoxicity remains unknown, although changes in specific miRNAs may either contribute to or protect against anesthesia-induced neurotoxicity.
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Journal of anesthesia · Dec 2019
Remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block in the isolated hemidiaphragm of the rat: an ex vivo study.
Sugammadex is used to reverse neuromuscular block induced by rocuronium or vecuronium by forming a stable complex. If the binding capacity of any substance to sugammadex is large enough, this molecule will displace rocuronium or vecuronium from the complex. For drugs used in anesthesia, the binding affinity of remifentanil for sugammadex was highest. The aim of the current study was to investigate the decrease in the reversal of neuromuscular blockade with sugammadex by complex formation between remifentanil and sugammadex in the model using isolated hemidiaphragm of the rat. ⋯ Clinical concentration of remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block. Sugammadex can be used safely without worrying about the interaction with remifentanil.
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The 95th KoreAnesthesia Meeting was held successfully over 3 days from November 8 to 10, 2018 at Seoul Dragon-City Hotelplex, featuring 62 overseas speakers and 2960 attendees from 26 countries. KoreAnesthesia is the largest annual event hosted by the Korean Society of Anesthesiologists (KSA). The KSA hopes that many members of the Japanese Society of Anesthesiologists and readers of the Journal of Anesthesia will join us at the forthcoming KoreAnesthesia 2019 from October 31 to November 2, 2019 at Paradise City Hotel, Incheon, South Korea.