Annals of medicine
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In patients with ST-elevation myocardial infarction (STEMI), pulmonary infection after successful primary percutaneous coronary intervention (PCI) is a severe complication that often results in death. It is not known whether there are any predictive markers for the onset of pneumonia in STEMI patients after successful PCI. ⋯ As a result of PCI for STEMI patients, the SIRI is a good indicator of pneumonia risk. The likelihood of pneumonia occurring in STEMI patients after PCI generally increases with increasing SIRI.
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To prepare a polyglycolic acid-loaded mitomycin drug (MMC-ATS-@PLGA) to inhibit scar proliferation after glaucoma filtering surgery (GFS) via an anti-inflammatory mechanism that minimally affected intraocular pressure, which provided another therapeutic strategy for this disease. ⋯ We successfully synthesized MMC-ATS-@PLGA, which could effectively inhibit scar proliferation after GFS via anti-inflammatory effects but had little effect on intraocular pressure. This new type of nanomedicine has good biosafety and stability and is worthy of further exploration in clinical practice.
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Chronic post-thoracotomy pain (CPTP) is characterized by high incidence, long duration, and severity of pain. Medial prefrontal cortex (mPFC) is a brain region closely associated with chronic pain, and norepinephrine is involved in pain regulation. But the role of mPFC norepinephrine in CPTP and its possible mechanism is unclear. ⋯ Inhibition of norepinephrine in contralateral mPFC after thoracotomy improved CPTP. The potential mechanisms may include rescuing the expression of AQP4 and IL-33, as well as reducing neuroinflammation and Bdkrb2 expression.
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Meta Analysis
Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis.
Janus kinase (JAK) inhibitors (JAKinibs) are effective for inflammatory bowel disease (IBD), but their cardiovascular safety is inconclusive. We aim to assess the cardiovascular risks associated with JAKinibs in IBD patients. ⋯ Although a trend of increased cardiovascular risks was found considering dose, no significantly increased cardiovascular risk was associated with JAKinibs in IBD patients, and Deucravacitinib significantly decreased the risks of VTE and CVE.
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Meta Analysis
Atherogenic index of plasma and the clinical outcome of patients with acute coronary syndrome: a meta-analysis.
The atherogenic index of plasma (AIP) has been related to an increased risk of coronary artery disease. However, previous studies evaluating the prognostic role of AIP for acute coronary syndrome (ACS) showed inconsistent results. This meta-analysis was conducted to systematically evaluate the association between AIP and the risk of major cardiovascular adverse events (MACE) of patients with ACS. ⋯ A high AIP is associated with an increased risk of MACE in patients with ACS, particularly for older patients.