Respiratory medicine
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Respiratory medicine · Apr 2018
Observational StudyDistinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia.
Interstitial lung diseases are heterogeneous, and patients with chronic fibrosing interstitial pneumonia (CFIP) often have clinical, serologic, and morphologic features suggestive but not diagnostic of connective tissue disease. Recently, the concept of interstitial pneumonia with autoimmune features (IPAF) has been proposed as a platform for such patients. However, the prognostic role of IPAF, including the cumulative incidence of acute exacerbations (AEs), is not fully clear. The aim of this study was to elucidate the clinical features and prognostic significance of IPAF. ⋯ A diagnosis of IPAF might predict a favorable prognosis and less risk of AEs in patients with CFIP.
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Respiratory medicine · Mar 2018
Randomized Controlled TrialInterstitial lung abnormalities are associated with increased mortality in smokers.
The aim of this study was to investigate whether smokers with incidental findings of interstitial lung abnormalities have an increased mortality during long-term follow-up, and review the contributing causes of death. ⋯ Interstitial lung abnormalities were common in this lung cancer screening population of relatively healthy smokers and were associated with mortality regardless of the interstitial morphological phenotype. The increased mortality was partly due to an association with lung cancer and non-pulmonary malignancies.
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Respiratory medicine · Mar 2018
Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases.
The impact of viral infections on acute exacerbations in idiopathic pulmonary fibrosis (IPF) and/or non-IPF interstitial lung disease (ILDs) has been scarcely described. ⋯ Viral infections, mostly CMV or HHV7, were identified in both patients with acute exacerbation of IPF and non-IPF ILDs, but the clinical significance on short-term mortality or isolation itself from respiratory samples remains to be determined.
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Respiratory medicine · Feb 2018
Comparative Study Observational StudyRecognition of unprovoked (idiopathic) pulmonary embolism-Prospective observational study.
The assessment of the clinical symptoms is the weakest link of the pulmonary embolism (PE) diagnostic algorithm. Despite the presence of highly sensitive and specific imaging methods, verifying PE remains difficult due to nonspecific clinical symptoms and frequently its subclinical course. ⋯ Unprovoked PE occurs at a younger age, more frequently in males. It is characterized by the following significant variables: higher Wells score, lower PESI score, lower CRP, higher thrombotic burden and lower one-month mortality rate, compared to provoked PE.
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Respiratory medicine · Feb 2018
Comparative StudyThe influence of psychiatric disorders on the course of lung cancer, chronic obstructive pulmonary disease and tuberculosis.
This Danish study evaluated the association between psychiatric comorbidity and the course of chronic obstructive pulmonary disease (COPD), lung cancer and tuberculosis (TB) of an entire nation. ⋯ To our knowledge, this is the first epidemiological study investigating the influence of a psychiatric comorbidity on the course of COPD, lung cancer and TB at a national level. Our results emphasize the importance of detecting these major respiratory diseases in patients with psychiatric comorbidities and intensifying the treatment and follow up of these patients.