Respiratory medicine
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Respiratory medicine · May 2012
Controlled Clinical TrialEffect of bariatric surgery on airway response and lung function in obese subjects with asthma.
Obesity is a risk factor for self-reported asthma and makes asthma management more difficult. The effects of bariatric surgery on asthma in severely obese subjects remain to be documented. ⋯ Airway responsiveness, lung volumes and asthma severity/control markedly improved with weight loss following bariatric surgery in severely obese patients.
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Respiratory medicine · May 2012
Electromagnetic navigation bronchoscopy (ENB): Increasing diagnostic yield.
To determine factors associated with diagnostic yield of ENB. ⋯ Diagnostic yield increased with experience but was independent from the size of the lesion, the localisation in the lungs, and lung function. The diagnostic yield of ENB can be as high as for CT-guided transthoracic biopsies but carries a significantly lower complication rate.
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Respiratory medicine · May 2012
A better response in exercise capacity after pulmonary rehabilitation in more severe COPD patients.
Pulmonary rehabilitation (PR) has positive effects on exercise capacity in Chronic Obstructive Pulmonary Disease (COPD). However, not all COPD patients benefit from PR to the same extent. We investigated whether there is a patient profile, which is associated with the improvement in endurance exercise capacity. ⋯ Single variables from lung function or exercise testing at baseline have limited predictive value for response to exercise training. However, patients with worse disease status (i.e. a combination of lower FEV(1), more hyperinflation, lower exercise capacity and worse quadriceps force) improve more in endurance exercise capacity.
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Respiratory medicine · Apr 2012
Randomized Controlled Trial Comparative StudyStrength training increases maximum working capacity in patients with COPD--randomized clinical trial comparing three training modalities.
Skeletal muscle dysfunction contributes to exercise limitation in patients with chronic obstructive pulmonary disease (COPD). Strength training increases muscle strength and muscle mass, but there is an ongoing debate on the additional effect concerning the exercise capacity. The purpose of this study was to compare the effects of three different exercise modalities in patients with COPD including endurance training (ET), progressive strength training (ST) and the combination of strength training and endurance training (CT). ⋯ Progressive strength training alone increases not only muscle strength and quality of life, but also exercise capacity in patients with COPD, which may have implications in prescription of training modality. CLINICALTRIALS.GOV IDENTIFIER: NCT01091623.
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Respiratory medicine · Apr 2012
Randomized Controlled Trial Multicenter StudyAZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD.
Neutrophil elastase (NE) is implicated in chronic obstructive pulmonary disease (COPD). AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses of 60 mg bid during Phase I/IIa development. ⋯ Three months' treatment with AZD9668 did not improve lung function, respiratory signs and symptoms or SGRQ-C score when added to budesonide/formoterol maintenance therapy in patients with COPD. In the absence of definitive biomarkers of short-term disease progression, further research is needed to determine the optimal duration of studies to evaluate NE inhibitors as disease-modifying agents.