Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Jul 2011
Cell-free DNA--a marker to predict ischemic brain damage in a rat stroke experimental model.
The animal model of stroke that is most frequently used is a rat model of focal brain ischemia caused by middle cerebral artery occlusion (MCAO). Several studies have reported a link between levels of cell-free DNA (CFD) and neurologic outcome in human stroke. The purpose of this study was to assess brain injury and measure CFD levels in 2 models of MCAO in rats, and to determine whether brain injury correlates with CFD. ⋯ We found that CFD levels correlate well with the extent of ischemic injury, brain edema, and neurologic outcome in rats 24 hours post-MCAO. We have also shown that CFD correlates well with the expected temporal progression of ischemic injury. These findings place CFD in a unique place as a biomarker for stroke, both experimentally and possibly clinically.
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J Neurosurg Anesthesiol · Jul 2011
Letter Case ReportsTakotsubo cardiomyopathy and the difficult airway.