Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Oct 2012
Historical ArticleThe history of neuroanesthesiology: the people, pursuits, and practices.
Neuroanesthesiology has a rich history. Although advances in research and clinical practice were cornerstones for the development of this field, other equally critical factors came into play. ⋯ This article reviews important advances within the subspecialty and many individuals behind those advances. The analysis and speculative synthesis provide insights into the current status of neuroanesthesiology and possible directions for the subspecialty's future.
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The third PANDA symposium on Anesthesia and Neurodevelopment in Children included a session on Patient Centered Outcomes Research. Three speakers were invited to discuss SmartTots, a private-public partnership between IARS and FDA, Wake Up Safe, a patient safety organization and lastly, NICHD/NIH funding for training in research. The session provided information related to ongoing efforts to improve outcome and safety of anesthesia care in children and introduced potential sources and mechanisms of federal and non-federal funding for research related to anesthetic neurotoxicity in the developing brain.
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J Neurosurg Anesthesiol · Oct 2012
Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia.
This study aimed to examine the effects of sevoflurane or isoflurane preconditioning on cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and lipid peroxidation and test the hypothesis that the underlining mechanism of the protective effect of preconditioning involves changes in the apoptotic gene expression profiles in an experimental model of middle cerebral artery occlusion in rats. ⋯ Sevoflurane and isoflurane preconditioning ameliorates inflammation, cerebral lipid peroxidation, and histologic injury. Downregulation of proapoptotic molecules and upregulation of antiapoptotic molecules may be associated with this effect.