Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Oct 2016
Microdialysis as a Part of Invasive Cerebral Monitoring During Porcine Septic Shock.
Metabolic changes in critically ill patients with endotoxin-induced septic shock are measured primarily by techniques that afford organ-specific metabolic monitoring based on interstitial fluid samples. The present study was designed to evaluate the role of cerebral microdialysis (MD) as a part of invasive neuromonitoring during endotoxemia in a porcine model. ⋯ Although our results confirm the special protection of the brain during endotoxemia compared with other organs, early metabolic changes become evident by increasing lactate/pyruvate ratio and lactate/glucose ratio. MD appears to be a suitable additional technique in invasive neuromonitoring for obtaining early information about metabolic deterioration in the brain during septic shock.
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J Neurosurg Anesthesiol · Oct 2016
Report on the Fifth PANDA Symposium on "Anesthesia and Neurodevelopment in Children".
On April 16 and 17, 2016, the Pediatric Anesthesia and Neurodevelopment Assessment (PANDA) study held its fifth biennial symposium at the Morgan Stanley Children's Hospital of New York. The PANDA symposium has served as a key forum for clinicians, researchers, and other major stakeholders to gather and review the current state of preclinical and clinical research related to anesthetic neurotoxicity in children. ⋯ It included clinicians, preclinical and clinical researchers as well as representatives from government organizations (FDA [Food and Drug Administration] and National Institutes of Health). A total of 135 attended the symposium.
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Neurotoxicity related to early exposure to various insults, both anesthesia-related and nonanesthesia-related, is a topic of ongoing and increasing interest. To better understand the process by which this might occur, the fifth PANDA Symposium convened a session in which 4 notable neuroscientists discussed current concepts and research in neurodevelopment, highlighting periods of particular susceptibility and ways in which neural connectivity and systemic functioning may be affected.