Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol
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J Neurosurg Anesthesiol · Jan 2015
Randomized Controlled Trial Comparative StudyA Comparison of Equivolume, Equiosmolar Solutions of Hypertonic Saline and Mannitol for Brain Relaxation in Patients Undergoing Elective Intracranial Tumor Surgery: A Randomized Clinical Trial.
Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The purpose of the study was to compare the effects of equivolume, equiosmolar solutions of mannitol and hypertonic saline (HTS) on brain relaxation and postoperative complications in patients undergoing elective intracranial tumor surgery. ⋯ Our results suggest that HTS provides better brain relaxation than mannitol during elective intracranial tumor surgery.