Journal of neurosurgical anesthesiology
-
Although the skull limits applicability of sonography, bedside intracranial endosonography might be an alternative to computed tomography scans to detect adverse events in sedated patients. However, the usefulness of intracranial endosonography for potential clinical application has not been evaluated. The present study was designed to investigate the suitability of an image-guided intracranial endosonography (IGIE) catheter for intracranial ultrasound imaging in an ex vivo phantom model and in a large animal model. ⋯ IGIE provides high-definition images of intracranial structures, Doppler analysis of blood flow, and real-time monitoring of intracranial structural lesions. We suggest that IGIE might prove a valuable tool for intracranial monitoring of sedated patients over extended time periods.
-
J Neurosurg Anesthesiol · Jul 2013
Randomized Controlled TrialEffect of intraoperative dexmedetomidine on postoperative recovery profile of children undergoing surgery for spinal dysraphism.
Smooth recovery from anesthesia is desirable in children undergoing surgery for spinal dysraphism who are nursed in prone position during the postoperative period. Dexmedetomidine may be beneficial in these children owing to its sedative, anxiolytic, and opioid-sparing properties with minimal respiratory depression. ⋯ Intraoperative use of dexmedetomidine in children undergoing spinal surgery results in a favorable recovery profile with reduced postoperative pain and EA, without adverse perioperative hemodynamic effects.
-
J Neurosurg Anesthesiol · Jul 2013
Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest.
Glioblastoma (GBM), the most common primary brain tumor, is the most aggressive malignancy in humans. Its rapid proliferation is a major obstacle to successful treatment. Patients with GBM often suffer from psychological disturbances associated with poor prognosis and physical discomfort. Diazepam is one of the most frequently used benzodiazepines (BZs) in cancer patients for its desirable psychotropic effects. The central effects of BZs are mediated by the activation of central BZ receptors. This study investigates whether diazepam has inhibitory effect on proliferation of GBM cell line T98G and explores its possible mechanism. ⋯ Diazepam inhibits the proliferation of human GBM T98G cells by inducing G0/G1 phase arrest. Diazepam has potential to be a lead for new drugs in GBM therapy because of its antitumor activity.
-
J Neurosurg Anesthesiol · Jul 2013
Pulsed radiofrequency for the suprascapular nerve for patients with chronic headache.
Chronic shoulder or suprascapular pain is a disabling phenomenon. Chronic headache is also a disabling phenomenon for many patients. Once it was believed that chronic headache that is attributed to the cervical spine originates from the upper cervical nerve roots (C0-C3). Currently, it is suggested by some authors that the reason for headache in many patients is attributed to the lower cervical nerve roots in the cervical spine. The suprascapular nerve originates from the C5 and C6 nerve roots and supplies the suprascapular and shoulder region. Pulsed radiofrequency (PRF) has gained popularity over recent years as a good clinical tool in treating patients with shoulder/suprascapular pain. It is usually considered as a treatment option after conservative treatment has failed. The purpose of this study was to evaluate whether PRF for the suprascapular nerve has also beneficial effect for patients that have also chronic headache that is attributed to the lower cervical nerve roots. ⋯ PRF for the suprascapular nerve is a safe and an effective procedure for patients who suffer from shoulder/suprascapular pain and also for headache that is attributed to the lower cervical nerve roots. It should be tried after conservative treatment has failed.