Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Apr 2013
Randomized Controlled TrialEfficacy and safety of local versus general anesthesia in stereotactic biopsies: a matched-pairs cohort study.
Frame-based stereotactic biopsies remain the gold standard for the diagnosis of intracerebral lesions. A major advantage is the ability to perform these procedures under local anesthesia (LA). However, there is no consensus on whether or when to use LA or general anesthesia (GA). It has been postulated that the use of LA may reduce the risk of complications. This study aims to objectify the efficacy and safety of stereotactic biopsies under LA versus GA by analyzing a prospective registry for stereotactic biopsies. ⋯ The type of anesthesia may not interfere with the diagnostic yield in stereotactic biopsies. Patients operated under LA are less likely to suffer pulmonary complications. Furthermore, LA could spare hospital resources in this setting.
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J Neurosurg Anesthesiol · Apr 2013
Postischemic sevoflurane offers no additional neuroprotective benefit to preischemic dexmedetomidine.
We designed this study to determine whether a combination of dexmedetomidine and sevoflurane postconditioning provides additive neuroprotection in a rat model of transient global cerebral ischemia. ⋯ A combination of preischemic dexmedetomidine and sevoflurane postconditioning provides no additional neuroprotective benefit over preischemic dexmedetomidine or sevoflurane postconditioning alone.