Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Jul 2011
Letter Case ReportsTakotsubo cardiomyopathy and the difficult airway.
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J Neurosurg Anesthesiol · Apr 2011
Randomized Controlled TrialGabapentin premedication decreases the hemodynamic response to skull pin insertion in patients undergoing craniotomy.
In patients undergoing craniotomy, skull pin insertion produces significant increases in heart rate (HR) and blood pressure. We investigated whether premedication with gabapentin would prevent or attenuate this increase. ⋯ In conclusion, 900 mg of gabapentin, administered orally 2 hours before induction of anesthesia along with lidocaine scalp infiltration abolished the hemodynamic response after skull pin insertion. Premedication with gabapentin alone significantly attenuated the SBP and MAP; however, HR responses were more variable. A larger trial is required to corroborate the findings of the study before clinical recommendations would be warranted.