Critical care nursing clinics of North America
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Maintenance of brain perfusion and oxygenation is of paramount importance to patient outcome with various types of brain injuries (traumatic, ischemic, and hemorrhagic). Historically, monitoring of intracranial pressure and cerebral perfusion pressure has been the mainstay of neuromonitoring techniques used at the critical care bedside to monitor brain perfusion and oxygenation. This article describes the bedside neuromonitoring techniques that have emerged for use with these patients in the critical care area. To give the reader an understanding of the functionality of these neuromonitoring techniques, the article first summarizes the physiology of brain perfusion and oxygenation.
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Crit Care Nurs Clin North Am · Sep 2014
ReviewThe physiologic role of erythrocytes in oxygen delivery and implications for blood storage.
Erythrocytes are not just oxygen delivery devices but play an active metabolic role in modulating microvascular blood flow. Hemoglobin and red blood cell morphology change as local oxygen levels fall, eliciting the release of adenosine triphosphate and nitric oxide to initiate local vasodilation. ⋯ This article reviews the functional anatomy and applied physiology of the erythrocyte and the microcirculation with an emphasis on how erythrocytes modulate microvascular function. The effects of cell storage on the metabolic functions of the erythrocyte are also briefly discussed.