Burns : journal of the International Society for Burn Injuries
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The provision and practice of burn care changed dramatically during the latter half of the 20th century. Historically, indicators of outcomes that were employed were survival and length of hospital stay, but these have now been expanded with increased data capture. ⋯ The multiple domains covered by the term "patient outcome" aim to optimize the acute and long-term management of burn patients and have shifted the focus onto lifelong outcomes, rather than short-term gains. This review will investigate the current outcome measures employed in burn care in the UK, how this leads to commissioning and regulation of a burn service, and influences the future direction of travel.
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Burns are important preventable causes of morbidity and mortality, with a disproportionate incidence in sub-Saharan Africa. The management of these injuries in sub-Saharan Africa is a challenge because of multiple other competing problems such as infectious diseases (HIV/AIDS, tuberculosis and malaria), terrorist acts and political instability. There is little investment in preventive measures, pre-hospital, in-hospital and post-discharge care of burns, resulting in high numbers of burns, high morbidity and mortality. Lack of data that can be used in legislation and policy formulation is a major hindrance in highlighting the problem of burns in this sub-region. ⋯ These statistics indicate the need for an urgent review of burn policies and related legislation across the sub-Saharan region to help reduce burns, and provide a safe environment for children.
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Acinetobacter baumannii is one of the important causes of nosocomial infection especially in burn patients. So, carbapenemase producing strains can make serious therapeutic problems. Molecular epidemiology studies play key role in decreasing the incidence of carbapenemase producing strains. ⋯ The results of this study were showed the presence of certain clonal groups in two different wards of hospital indicating the spread of carbapenemase producing A. baumannii. On the other hand, the results showed the more discriminating power for PFGE.
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Severe burn is known to induce a series of pathological responses resulting in increased susceptibility to systemic inflammatory response and multiple organ failure, but the underlying molecular mechanism remains unclear at present. The main aim of this study was to expand our understanding of the events leading to circulating leukocyte response after burn by subjecting the gene expression profiles to a bioinformatic analysis. ⋯ Based on an integrated bioinformatic analysis, we concluded that Lck, Jun, Cd19, Stat1, and Cdk1 may be critical 1 day after the burn. These findings expand our understanding of the molecular mechanisms of this important pathological process. Further studies are needed to support our work, focused on identifying candidate biomarkers with sufficient predictive power to act as prognostic and therapeutic biomarkers for burn injury.
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The aim of this study was to evaluate the effects of green LED light on inflammatory cells in skin burns: a histological study in rats. ⋯ Green LED light provides an anti-inflammatory effect on skin burns of rats.