Burns : journal of the International Society for Burn Injuries
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Pressure therapy has been widely used in clinical practice for the prevention or treatment of hypertrophic scars resulted from aberrations in wound healing. However, the precise molecular mechanisms of this process are only partially understood. In the present study, we established a Bama minipig model to observe the effect of pressure intervention on wound healing and scar formation. ⋯ Interestingly, the trend in MEK/ERK protein expression was opposite to that indicated by q-PCR analysis. Furthermore, collagen I and III mRNA clearly declined after one month pressure treatment. Taken together, these results indicated that pressure intervention alleviated scar formation may via inhibiting the IGF-1/IGF-1R signaling pathway and collagen expression in the Bama minipig model.
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The purpose of this study is to investigate the potential use of computed tomography (CT) in assessing inhalation injuries at various levels by studying the changes in lung imaging of rabbits with severe inhalation injury. ⋯ A lung CT scan is able to reflect the early-stage lung injuries of rabbits with different levels of severe inhalation injury.
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This study was conducted to determine the epidemiological and clinical characteristics of burn injuries, estimate the case fatality rate for burn patients, and determine the main determinants of the associated death among burn patients who were admitted to Baghdad Burn Hospital, Medical City Teaching Hospitals, Baghdad, Iraq during 2015. This study involved a retrospective review of medical records of all burn patients who were admitted to Baghdad Burn Hospital in 2015. Data were collected using a special form and included information on demographic characteristics and burn characteristics and outcomes. ⋯ In conclusion, young adults and children, males, and low educated patients represent the majority of admitted burn cases in Iraq. Flame and scalds were the most important causes of burn. More than one tenth of patients died mostly due to septicemia and multi-organ failure.
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Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns. ⋯ This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy.