Burns : journal of the International Society for Burn Injuries
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This was a methodological study whose objective was to culturally adapt the 5-D itch scale for Brazilian Portuguese and verify its practicability, acceptability and reliability for burn survivors. This study followed the five internationally recommended steps for the adaptation process: translation, synthesis, back translation, assessment by an expert committee and pretesting process; besides, an evaluation of its practicability, acceptability and reliability was conducted. The pretest was carried out with thirty burn survivors - hospitalized or on outpatient follow-up - from two public hospitals in the state of São Paulo. ⋯ The Brazilian version had semantic and idiomatic, conceptual and cultural equivalences, with a satisfactory content validity index for each item (CVI-I). Mean application time was 3.5minutes, acceptability was good, and there was evidence of reliability for the total score (0.793). The Brazilian version of the 5-D itch scale showed equivalence and evidence of reliability for assessing pruritus and its impact in burn survivors.
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Patients with major burns covering a large total body surface area (%TBSA) fulfill all the criteria of Virchow's triad, as a sequela of their injury. This places these patients at increased risk for developing deep vein thrombosis (DVT). However, data regarding the incidence of DVT in burn patients are minimal, especially in the pediatric age group. Therefore, the aim of this study is to determine the incidence of DVT in pediatric burn patients, identify possible risk factors for developing DVT, and explore the need for prophylactic treatment. ⋯ Burns are a major risk factor for DVT, especially when covering large surface areas (≥40% TBSA) and combined with other factors (i.e., prolonged hospitalization and central lines). Thus, investigations for DVT and prophylactic anticoagulation should be considered for pediatric burn patients with these risk factors, even if they are asymptomatic.
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Oxandrolone is a synthetic oral non-aromatizable testosterone derivative. This drug has been used successfully for several decades to safely treat growth delays in various diseases including Turner's syndrome. Currently the use of oxandrolone is under clinical testing in children with burn injury; the available data indicate that the anabolic steroid increases net muscle protein balance, maintains lean body mass, and reduces intensive care unit stay. ⋯ Multiple burn-induced inflammatory mediators (TNF-α, IL-1α, IL-1β, IL-4, IL-6, IL-10, IL-12, IP-10, G-CSF, GM-CSF and interferon-γ) were significantly lower in the plasma of oxandrolone-treated animals after burn injury than in the plasma of controls subjected to burns. Finally, oxandrolone significantly accelerated burn wound healing. We conclude that oxandrolone improves organ function, modulates the systemic inflammatory response and accelerates wound healing in a murine model of burn injury.