Burns : journal of the International Society for Burn Injuries
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In this research, a novel semi-interpenetrating hydrogel network comprised of polyethylene glycol diacrylate (PEGDA)/polyvinyl alcohol (PVA)/tragacanth gum (TG) with adaptable mechanical, biological, and physical characteristics was fabricated for wound healing purposes. The chemical structure of the films and the surface morphology were examined by FTIR and SEM, respectively. In addition, swelling ratio, mechanical characteristics, water vapor transmission rate (WVTR), gel fraction, and degradability of the hydrogels were assessed. ⋯ The results verified the non-toxic nature of PEGDA/PVA/TG hydrogel networks. Finally, the antibacterial results demonstrated that the highest antibacterial activities against bacterial pathogens is related to the TG-containing film. Therefore, PEGDA/PVA/TG hydrogel networks can be favorable wound dressings.
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Wound injury is common and causes serious complications if not treated properly. The moist dressing heals wounds faster than other dressings. Therefore, we sought to study the effect of hesperidin/naringin hydrogel wound dressing or their combinations on the deep dermal wounds in mice. ⋯ Application of 5% hesperidin hydrogel was more effective than 5% naringin or combination of hesperidin and naringin gels (1:1, 2:1 or 1:2) indicated by a greater wound contraction, reduced mean wound healing time, elevated collagen and DNA syntheses, rise in glutathione concentration, and superoxide dismutase activity followed by reduced lipid peroxidation, and NF-κB, and COX-2 expression.