Burns : journal of the International Society for Burn Injuries
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Burns are dynamic injuries characterized by an initial zone of necrosis that progresses to compromise surrounding tissue. Acute inflammation and cell death are two main factors contributing to burn progression. These processes are modulated by Connexin43 (Cx43) hemichannels and gap junctions in burns and chronic wounds. ⋯ Quantitative analysis using H&E, Masson's trichrome & Picrosirus Red revealed reduced epidermal thickness and improved collagen preservation in treated burn wounds. Collectively, our findings suggest a possible involvement of the Cx43-mediated NLRP3 inflammasome pathway via P2X7 activation in early burn wound healing. This indicates that targeting Cx43 may have a potential therapeutic effect to improve healing outcomes.
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Health and racial disparities can limit access to preventative, trauma, and chronic disease care but have not been addressed in burn resuscitation. Over- and under-resuscitation contribute to increased overall hospital costs, and morbidity and mortality rates. The primary objective of this study was to identify potential racial disparities that may exist during the initial fluid resuscitation after burn injury. ⋯ Overall mortality was not higher in the AA-HIS group at 32.6 % vs 17.7 % (p = 0.081). There were no differences in amount of fluid administered, urine output, laboratory values during resuscitation, or patient outcomes between the groups. The use of protocols for burn resuscitation can be instrumental in protecting against racial and ethnic disparities.
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The aim of this investigation was to conduct a thorough synthesis of the extant scholarly discourse and to delineate the prevailing global trends in the domain of burn pain, employing a bibliometric analysis. ⋯ Research on burn pain is advancing rapidly; however, collaboration among countries and institutions remains limited. Increased cooperation and communication across these entities could significantly advance the field in the future. Future research should prioritize placebo-controlled trials of targeted therapeutic drugs and innovative pain management approaches, with a strong emphasis on patient outcomes and quality of life.
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The Brisbane Burn Scar Impact Profile (BBSIP) and the Patient and Observer Scar Assessment Scale (POSAS) are used in burn scar assessment to quantify patient health-related quality of life (HR-QoL). These questionnaires were developed using pen-and-paper delivery methods; however, there is a push towards electronic delivery of these questionnaires in both clinical practice and research. Equivalence testing is required to ensure that validity of these paper questionnaires is maintained electronically. ⋯ Findings generally support electronic delivery of the BBSIP and POSAS, likely supporting their use in outpatient clinics, telehealth clinics, and remote monitoring. Additional testing is required for subscales that did not demonstrate equivalence.