Burns : journal of the International Society for Burn Injuries
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Oral commissure stenosis and lower eyelid ectropion from burns are functionally impairing and challenging to treat. Evaluation of various treatment modalities is limited by a lack of preclinical models. Described is a method for inducing controlled, titratable oral commissure and lower eyelid burns in swine for future treatment research. ⋯ Oral commissure and lower eyelid burns create scars which may be modified by burn duration. This model may evaluate a therapeutic's ability to limit functional impairment from burns.
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Many research-based burn models rely on creating homogenous burns that are subsequently studied and treated. However, the majority of burn wounds sustained - and in particular those that are combat-related - are heterogeneous in nature, with varying degrees of severity intermixed throughout the entire wound, creating a complex debridement and overall treatment plan. The purpose of this study was to develop a clinically relevant heterogeneous porcine burn wound model. ⋯ The heterogeneity of burn wounds creates a clinical challenge. This model will help to create burns that are more similar to the heterogeneous burn wounds that are seen in clinical practice and will help further research efforts in treating burns.
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Meta Analysis
The efficacy of cellulose dressings in burn wound management: a systematic review and meta-analysis.
Burn wound management is challenging, especially in paediatric patients when optimising outcomes. Superficial burns are generally managed conservatively with dressings; however, frequent dressing changes can be a source of pain and discomfort. Cellulose dressings mitigate these problems, and current reports in the literature have demonstrated positive outcomes when compared against routine dressing types. The authors aim to report a systematic review and meta-analysis on the use of cellulose-based dressings in burn wound management. ⋯ Cellulose dressings can expedite wound healing whilst reducing the duration of hospitalisation and frequency of dressing changes compared to standard dressings in burn wound management. The authors however recommend further high quality trials to enhance the current evidence base.
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Hypertrophic scars and keloids are forms of pathologic scarring that can give rise to pain and pruritus. The link between nerve function and nerve density and the symptoms in pathologic scars (PS) remains unclear. ⋯ Wide heterogeneity between studies exists. Therefore, no firm conclusions can be formulated. However, evidence suggests involvement of the cutaneous nervous system by neurogenic inflammation in the pathophysiology of pathologic scars and their symptoms.