Burns : journal of the International Society for Burn Injuries
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Shedding of syndecan-1 from the endothelial glycocalyx layer (EGL), referred to as endotheliopathy of trauma (EoT), is associated with poorer outcomes. This study aims to determine if EoT is also present in the burn population. We enrolled 458 burn and non-burn trauma patients at a Level 1 trauma center and defined EoT by a syndecan-1 level of ≥40 ng/mL. ⋯ EoT is attributed to the shock rather than the mechanism of trauma and may in burns be associated to II rather than TBSA. Patients with burns and II had worse outcomes and higher mortality compared to patients with burns alone. Burn injury induces EGL shedding similar to that in non-burn patients with EoT, and results in similar higher rate of mortality.
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Guided by the Transactional Model of Stress and Coping, this study seeks to (1) examine the independent relationships between the level of distress among burn survivors, pre-morbid psychiatric history, and burn severity on length of hospital stay, and (2) to examine the relationship between having a premorbid psychiatric history and level of distress following a burn injury. ⋯ A need exists to assess for and address premorbid and current mental health challenges of burn survivors, specifically the ability to cope, especially among people of color and women, regardless of the burn size or severity.
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Literature indicates that children from ethnic minorities are at increased risk of sustaining burns. Moreover, parents may experience more psychological distress but why this is the case is poorly investigated. ⋯ Parents with an ethnic minority background are at risk to experience increased distress after their child's burn injury. By exploring the aforementioned factors, health care professionals may increase the family's wellbeing. It may provide a starting point to offer tailored help.
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Detailed quantitative analysis of results, influence of position within logistic systems and consequence of dangerous goods ammonia has been done based on a sample of 1165 workers or third persons involved in 295 accidents. Results of accidents for those involved have been classified as unhospitalized, hospitalized survived, hospitalized deceased and killed. From the logistic point of view accidents with ammonia are located in production, storage, reloading, transport and use subsystems. ammonia's consequences are systematized in the following manner: Respiratory-Toxic (RT), Cold Injury (CI), Fire and Burns (FB), and mechanical consequences after explosions (EX). ⋯ Cold Injury by ammonia in 47.5% of accidents includes 65.23% of persons involved in accident, but the most invasive consequence of ammonia is RT. Significantly critical fatal outcomes of accidents has been found for Respiratory-Toxic consequence of ammonia in the reloading subsystem, with extremely high average value of 0.4193 killed per accident. Based on obtained results of research certain procedures are proposed to reduce the risk of serious consequences of ammonia's dangerous influence.
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Skin grafts are widely used in plastic and reconstructive surgery. Increasing the early vascularization of skin grafts is a key factor in improving skin grafting. In this study, we use platelet-rich plasma gel as an adipose-derived stem cell scaffold to assist the growth of rat skin grafts. ⋯ Using a Lewis rat model, we found the PRP gel + ADSCs significantly improved the properties of the transplanted skin grafts, increased the skin thickness and improved the collagen arrangement. PRP gel + ADSCs promoted skin neovascularization by elevating the expression of the vascularization factors VEGF, BFGF and PDGFB. Taken together, our study indicated that ADSCs combined with PRP have a potentiation effect on improving skin grafts by promoting angiogenesis, providing an innovative approach and a theoretical basis for its clinical application.