Burns : journal of the International Society for Burn Injuries
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Randomized Controlled Trial
Evaluation of the analgesic effects of duloxetine in burn patients: An open-label randomized controlled trial.
To evaluate efficacy of addition of duloxetine to usual analgesic regimens in management of burn pain. ⋯ Addition of duloxetine may increase efficacy of the other analgesics in reduction of the burn pain.
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The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11-46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. ⋯ OCT is a useful tool to quantify MT changes in the airway following SII and burns. OCT may be effective as a diagnostic tool in the early stages of SII-induced ARDS and should be tested in humans.
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Ephrin ligand/Eph receptor signaling is important in both tissue development and homeostasis. There is increasing evidence that Ephrin/Eph signaling is important in the skin, involved in hair follicle cycling, epidermal differentiation, cutaneous innervation and skin cancer. However, there is currently limited information on the role of Ephrin/Eph signaling in cutaneous wound healing. ⋯ The loss of Ephrin-A2 and A5 ligands did not impact on the rate of wound closure or re-innervation after injury. However, changes in the gross morphology of the healed scar and in collagen histology of the scar dermis were observed in transgenic mice. Therefore Ephrin-A2 and A5 ligands may play an important role in final scar appearance associated with collagen deposition and structure.
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Global use of the internet has become commonplace, and smart phones have paved the way for technological mobility. Incorporation of smart phone technology has the potential to positively affect health outcomes through use of health-directed applications (apps), particularly for those patients living in medically underserved areas. The Bridge Mobile App for Burn Patients (fka: HealthySteps), is a pilot project that was developed to address the unique recovery needs of patients with major burn injuries who are being discharged from a regional burn center. ⋯ Original recovery-stage appropriate bio-psycho-social content, instructional videos and links to burn-supportive web sites are delivered directly to patients' smart phones for the first 90days following discharge. The primary goal for the Bridge App is to decrease unplanned hospital re-admissions, while supporting increased quality of life and resilience in short-term recovery. In addition, the Bridge Mobile App is designed to collect patient data reflecting pain, anxiety, mood, itching, medication compliance, social participation, self-efficacy and return to work on a password protected, HIPPA compliant, encrypted mainframe.
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Surviving the first episode of bacteremia predisposes burn casualties to its recurrence. Herein, we investigate the incidence, mortality, bacteriology, and source of infection of recurrent bacteremia in military burn casualties admitted to the U.S. Army Institute of Surgical Research Burn Center over a 10year period. ⋯ Recurrent bacteremia increases mortality in military burn casualties. Additional research is needed to address and mitigate the underlying causes, thereby improving survival.